ABSTRACT
Background: An unprecedented and unexpected COVID-19 pandemic resulted appalled lock-downs limiting movement of the entire population of the country and also across the globe. Downtime due to COVID-19 pandemic, led to adjournment of schools, colleges, different institutions, industries and business. This shutdown of work affected physical, mental and behavioral health of mankind from different age groups of different sectors. Methods- In this cross-sectional study, prevalidated questionnaire using the quick mode of communications like Whatsapp and emails through Google form was used. It was among the quick and inexpensive method to collect data from a wide cross-section of the general public. After ethical committee approval, link was distributed among health care trainee, employees and health care workers (HCWs) of various educational institutes and hospitals. Participants read informed consent for voluntary participation in the survey, which was administered in two parts: The first part asked participants basic demographic characteristics including age, gender, place of residence and in second part questions were asked to determine participation in specific behaviors related to their physical, mental and behavioral health. Result(s): Physical-Significant change in exercise habits was found in 45.3% participants who exercised daily and 32.7% participants did 2 to 3times exercise in a week but 22% participants did not follow any exercise routine. Mental-This study reveals profound impact of lockdown on mental fitness variables as well. Lockdown induced lack of regular work schedules changed sleep habits of 45.8% participants. Behavioral-As precautionary measure 76% of the participants washed their hands mostly 5-7times throughout the day and 84.2% among them followed 6-steps of hand hygiene. 95.5% of participants used mask compulsorily. Conclusion(s): This survey is an attempt to study knowledge and behaviors of people in face of current pandemic where more than 1.3 billion people are inside their homes since lockdown. Although lockdown is effective measure to reduce the spread of COVID-19 there are reasons to be concerned. Prolonged home confinement and shutdown of work affects physical, mental and behavioral health of people. People feel socially isolated due to lockdown however social media platforms offer an opportunity to ameliorate social isolation. The effect on lockdown on physical, mental and behavioral routine habits can give inside of how people are living under impact of lockdown and the findings can reveals the impact of these never seen restrictions on life of people.Copyright © 2022 Ubiquity Press. All rights reserved.
ABSTRACT
Background: An unprecedented and unexpected COVID-19 pandemic resulted appalled lock-downs limiting movement of the entire population of the country and also across the globe. Downtime due to COVID-19 pandemic, led to adjournment of schools, colleges, different institutions, industries and business. This shutdown of work affected physical, mental and behavioral health of mankind from different age groups of different sectors. Methods- In this cross-sectional study, prevalidated questionnaire using the quick mode of communications like Whatsapp and emails through Google form was used. It was among the quick and inexpensive method to collect data from a wide cross-section of the general public. After ethical committee approval, link was distributed among health care trainee, employees and health care workers (HCWs) of various educational institutes and hospitals. Participants read informed consent for voluntary participation in the survey, which was administered in two parts: The first part asked participants basic demographic characteristics including age, gender, place of residence and in second part questions were asked to determine participation in specific behaviors related to their physical, mental and behavioral health. Result(s): Physical-Significant change in exercise habits was found in 45.3% participants who exercised daily and 32.7% participants did 2 to 3times exercise in a week but 22% participants did not follow any exercise routine. Mental-This study reveals profound impact of lockdown on mental fitness variables as well. Lockdown induced lack of regular work schedules changed sleep habits of 45.8% participants. Behavioral-As precautionary measure 76% of the participants washed their hands mostly 5-7times throughout the day and 84.2% among them followed 6-steps of hand hygiene. 95.5% of participants used mask compulsorily. Conclusion(s): This survey is an attempt to study knowledge and behaviors of people in face of current pandemic where more than 1.3 billion people are inside their homes since lockdown. Although lockdown is effective measure to reduce the spread of COVID-19 there are reasons to be concerned. Prolonged home confinement and shutdown of work affects physical, mental and behavioral health of people. People feel socially isolated due to lockdown however social media platforms offer an opportunity to ameliorate social isolation. The effect on lockdown on physical, mental and behavioral routine habits can give inside of how people are living under impact of lockdown and the findings can reveals the impact of these never seen restrictions on life of people. Copyright © 2022 Ubiquity Press. All rights reserved.
ABSTRACT
Background: Since the emergence of coronavirus disease 2019 to date, there is no available approved drug or definitive treatment for coronavirus disease 2019 viral infection, and the identification of novel hits against therapeutic targets has become a global emergency. Echinacea purpurea is a traditional herb utilized to treat cough, fever, sore throat, respiratory tract infection, and so on as an immune stimulant. In this study, in silico molecular docking approach was used to screen phytocompounds from E. purpurea against severe acute respiratory syndrome coronavirus 2 main protease 3C-like protease (3CLpro) and severe acute respiratory syndrome coronavirus main peptidase (96% sequence similarity) to blunt the viral gene expression and viral replication.
ABSTRACT
The aim of the present research work is to screen and assess the selected plant alkaloids as potential COVID-19 main protease enzyme (Mpro) inhibitors, using molecular docking study. We have selected several plant alkaloids which are having antiviral activity which includes berberine, columbamine, leurocristine, lycoricidine, lycorine, narciclasine, palmitine, periformaline, perivine and vincaleucoblastine used as ligands to study the interaction with selected target of COVID-2019. Nelfinavir and lopinavir were used as standard antiviral agents for comparison. COVID-19 Mpro was docked with selected compounds using PyRx 0.8 and docking was analysed by PyRx 0.8 and Biovia Discovery Studio 2019. The binding energies obtained from the docking of 6LU7 with lopinavir, nelfinavir, berberine, columbamine, leurocristine, lycoricidine, lycorine, narciclasine, palmitine, periformyline, perivine and vincaleucoblastine were -8, -8.3, -6.8, -7, - 6.5, -7.8, -7, -8.1, -7.3, -7.2, -7.3 and -7.3 kcal/mol, respectively. From the binding energy calculations we can conclude that nelfinavir and lopinavir may represent potential treatment options and berberine, columbamine, leurocristine, lycoricidine, lycorine, narciclasine, palmitine, periformyline, perivine and vincaleucoblastine found to possess the best inhibitors of COVID-19 Mpro.
ABSTRACT
Objectives: The objective of the study was to screen and assess the selected bioactive bioflavonoids in medicinal plants as potential coronaviruses (CoV) main protease (Mpro) inhibitors using molecular docking studies. Methods: We have investigated several bioflavonoids which include apigenin, galangin, glycitein, luteolin, morin, naringin, resveratrol, and rutin. Nelfinavir and lopinavir were used as standard antiviral drugs for comparison. Mpro was docked with selected compounds using PyRx 0.8 and docking was analyzed by PyRx 0.8 and Biovia Discovery Studio 2019. Results: The binding energies obtained from the docking of 6LU7 with native ligand, nelfinavir, lopinavir, apigenin, galangin, glycitein, luteolin, morin, naringin, resveratrol, and rutin were found to be −7.4, −8.3, −8.0, −7.8, −7.3, −7, −7.4, −7.6, −7.8, −6.9, and −9 kcal/mol, respectively. Conclusion: From the binding energy calculations, we can conclude that nelfinavir and lopinavir may represent potential treatment options and apigenin, galangin, glycitein, luteolin, morin, naringin, resveratrol, and rutin found to possess the best inhibitors of CoV disease-19 main protease.
ABSTRACT
The aim of the present research work is to screen and assess the selected plant alkaloids as potential COVID-19 main protease enzyme (Mpro) inhibitors, using molecular docking study. We have selected several plant alkaloids which are having antiviral activity which includes berberine, columbamine, leurocristine, lycoricidine, lycorine, narciclasine, palmitine, periformaline, perivine and vincaleucoblastine used as ligands to study the interaction with selected target of COVID-2019. Nelfinavir and lopinavir were used as standard antiviral agents for comparison. COVID-19 Mpro was docked with selected compounds using PyRx 0.8 and docking was analysed by PyRx 0.8 and Biovia Discovery Studio 2019. The binding energies obtained from the docking of 6LU7 with lopinavir, nelfinavir, berberine, columbamine, leurocristine, lycoricidine, lycorine, narciclasine, palmitine, periformyline, perivine and vincaleucoblastine were-8, -8.3, -6.8, -7, - 6.5, -7.8, -7, -8.1, -7.3, -7.2, -7.3 and -7.3 kcal/mol, respectively. From the binding energy calculations we can conclude that nelfinavir and lopinavir may represent potential treatment options and berberine, columbamine, leurocristine, lycoricidine, lycorine, narciclasine, palmitine, periformyline, perivine and vincaleucoblastine found to possess the best inhibitors of COVID-19 Mpro. Copyright © Journal of Global Trends in Pharmaceutical Sciences.